Related Themes

Discovery Science

Population-based interventions

Related Institutions

Prof. Michael Müller

Professor of Nutrigenomics and Systems Nutrition

Nutrigenomics and Systems Nutrition

people.uea.ac.uk/michael_muller

michael.muller@uea.ac.uk

My research interest is to develop novel dietary strategies to delay ageing of the gut-liver axis and involves the fields of molecular nutrition, physiology immunometabolism and the health effects of dietary components, such as dietary fibres. The gut-liver axis refers to the bidirectional relationship between the gut and its microbiota, and the liver, resulting from the integration of signals generated by dietary, genetic and environmental factors. The control of the microbiota is critical to maintaining homeostasis of the gut-liver axis, and as part of this bidirectional communication the liver shapes intestinal microbial communities. The role of diets in the related bidirectional relationship between the gut, along with its microbiota, and the liver is still poorly defined. We hypothesize that dietary fibres are essential food components with mode of actions not just in the colon but also in the small intestine and thereby having a profound impact on the function of the gut-liver axis e.g., glucose and bile acid metabolism. Our research will shed more light on why Western style diets depleted in essential food components such as dietary fibres have a pathophysiological impact on healthy aging possibly via a disturbed function of the gut-liver axis.