Prof. Maria O’Connell
Professor of Cell Biology/Head of Pharmacology
Maria’s research is focused on the role, prevention and treatment of inflammation in age-related diseases, including cancer.
1) Natural products for the prevention and treatment of inflammation and cancer. Plants provide an abundance of compounds with therapeutic potential. Plant compounds found in the foods we eat may also have potential as nutraceuticals in the prevention of age-related diseases. The O’Connell group investigate plant natural products including peptides, triterpenes, flavonoids and vitamins for their anti-tumorigenic and anti-inflammatory effects and the intracellular mechanisms involved.
2) Novel therapeutics for inflammatory diseases and cancer. The O’Connell group investigate (i) the role of the Nrf family in acute and chronic inflammation and cancer and the development of novel therapeutics targeting this pathway and (ii) cellular mechanisms of action of novel protein-protein interaction inhibitors and metal complexes targeting inflammation and cancer.