Related Themes

Discovery Science

Related Institutions

Dr Naiara Beraza

Career track group leader

Mechanisms mediating maintenance of health and disease progression; Role of metabolism in controlling liver and intestinal homeostasis and in underpinning host-microbe interactions

quadram.ac.uk/people/naiara-beraza/

Naiara.Beraza@quadram.ac.uk

Research in Dr Naiara Beraza’s group focuses on defining the mechanisms underpinning the gut-microbiome-liver axis communication during the initiation and progression of chronic disease, with a view to translate our findings to the clinical practice to treat liver disease and prevent cancer development.

She has recently described the mechanistic role of specific metabolic regulators in mediating the progression of chronic cholestatic disease. She has also defined the relevance of intestinal macrophages in regulating intestinal function and the composition of the microbiome that overall contribute to the progression of this chronic condition.

Taking advantage of her expertise and broad range of pre-clinical models of chronic liver disease, the collaboration with immunologists, microbiologists and bioinformaticians and her links with clinicians she is currently focusing on:

  • Defining how metabolism regulates innate immunity and its impact on the pathogenesis of chronic liver disease.
  • Understanding how host metabolism and immunity influence the intestinal microbiome and its contribution to the initiation and progression of liver disease.
  • Testing therapeutic strategies based on the modulation of the microbiome to treat chronic liver disease and prevent cancer development.